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Pre-Implantation Genetic Diagnosis (PGD)

If you or your partner carry the risk of inherited conditions, such as birth defects or genetic disorders, you may decide to undertake some genetic testing as part of your fertility treatment program.


Who should consider PGD?

If you are concerned about any of the following issues, PGD may give you peace of mind – and help us select an unaffected embryo for transfer.

  • Risk of your baby inheriting a known genetic condition
  • Known family history of chromosome rearrangement in your or your partner

Some of the single gene disorders we can test for include Huntington’s Disease, Cystic fibroisis, Thalassaemia and Fragile X. Please discuss any genetic concerns or risks with your fertility specialist to find out more about this procedure.


What is Pre-implantation Genetic Diagnosis?

Pre-implantaton genetic diagnosis or PGD is a highly sophisticated technique that tests embryos for a specific genetic or chromosomal abnormality. It allows us to select embryos that are not affected with the condition being tested for, prior to implantation and pregnancy. PGD is offered in conjunction with an IVF cycle.

For PGD for chromosomal anomalies such as Robertsonian translocaton and, genetic mutations such as thalassaemia, a biopsy of the blastocyst is usually performed where a few cells (3-5 cells) are taken from the trophectoderm. This approach significantly reduces the chance of a misdiagnosis as compared with one or two cells taken from an 8-cell embryo. The outcome of pregnancy after the transfer of a biopsied normal blastocyst is better than the transfer of a biopsied normal 8-cell embryo.

Preimplantation genetic diagnosis (PGD) is being used increasingly at the fertility Institutes to dramatically improve the chance of a successful IVF pregnancy in couples where prior IVF failures have remained unexplained. It has been estimated that over half of all IVF failures are not able to be explained by an apparent problem with embryo "quality". For many couples however, this statistic is quite misleading. AngelLife IVF embryologists looks very closely at the appearance of embryos under the microscope as they attempt to determine a "good" or "high quality" embryo from those of lesser quality. Generally, embryos are given "good" marks when they demonstrate an appropriate number of cell divisions at a given time in their growth cycle, when the individual cells of the embryo appear to have a uniform size and when there is an absence of cellular "fragments" that may or may not represent problems in the growth progress of the embryo.


Successful Use of PGD for Recurrent IVF Failure

Most couples presenting to us for consideration of PGD have one of the following conditions:

  • Prior unexplained IVF failure
  • Recurrent miscarriages
  • Maternal age over 38
  • Conception of a chromosomally abnormal child or fetus
  • Polycystic ovary syndrome
  • History of ovarian hyperstimulation syndrome
  • Heritable medical condition in either the patient or in a prior child (such as hemophilia)
  • Two or more children of the same gender (gender selection for family balancing)
  • Multiple birth with desire to transfer just one embryo or a need for donor oocytes due to Turner's syndrome
  • Premature ovarian failure or premature menopause

Using PGD to select the best embryos is clearly superior to traditional methods of selection. Miscarriage rates following PGD are far less than with standard IVF. Currently more than half of couples with two or more normal embryos and maternal age under 41 will take home a baby on a first IVF-PGD attempt in our program. And these are in couples who have failed multiple prior IVF attempts elsewhere!

Why Choose Us
Initial Consult
Couple visit Indira IVF center for Consultation and tests.
Pregnancy Test
After 2 weeks of embryo implantation, a pregnancy test is done to test whether woman is pregnant or not.
Fertilization
Eggs and Sperms are brought in contact in controlled lab environment for fertilization to occur. Embryos are formed as a result of fertilization.
Trigger Shot
A final trigger shot is given for maturation of eggs before retrieval.
Growth Monitoring
The egg growth is monitored on daily basis through ultra sound.
Ovarian Stimulation
Female partner is provided with medications to stimulate ovaries for producing better quality and quantity of eggs.
Sperm Retrieval
Sperm sample from male partner is retrieved through ejaculation or through TESA/PESA Procedure.
Embryo Implantation
After 3 to 5 days of Fertilization, embryo(s) is/are implanted to females Uterus where it attaches it self to the uterine lining for pregnancy to occur.
Best Discovery Tool
We provide information of over 5000 Fertility Hospitals & Doctors for IVF, IUI, ICSI, Pregnancy, Sexologists and Surrogacy Treatments.
Egg Retrieval
Eggs are Retrieved from woman's ovaries under sedation.
Inital Screening
Sperm analysis of male partner where as female reproductive system and follicle count is analysed through ultra sound.
Clear Pricing with no hidden costs
Our Service is completely FREE to its patients and users. Moreover, we make sure that fertility centres and doctors are committed to providing a transparent pricing structure for all fertility treatments.
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